FLNA Antibody

• Background:

  Actin-binding protein 280, or filamin, is a 280-kD protein that crosslinks actin filaments into orthogonal networks in cortical cytoplasm and participates in the anchoring of membrane proteins for the actin cytoskeleton. Remodeling of the cytoskeleton is central to the modulation of cell shape and migration. Filamin A, encoded by the FLNA gene, is a widely expressed protein that regulates reorganization of the actin cytoskeleton by interacting with integrins, transmembrane receptor complexes, and second messengers.

• NCBI Gene ID:

  2316

• Swiss Prot:

  P21333

• Accession Number:

  P21333

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This FLNA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1025-1054 amino acids from human FLNA.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  281 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  FLNA

• NCBI Official Name:

  Filamin-A

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ravid, D., Exp. Cell Res. 314 (15), 2762-2773 (2008)

• Background Reference 02:

  Maceyka, M., Mol. Cell. Biol. 28 (18), 5687-5697 (2008)

• Other Product Names:

  Filamin-A, FLN-A, Actin-binding protein 280, ABP-280, Alpha-filamin, Endothelial actin-binding protein, Filamin-1, Non-muscle filamin, FLNA, FLN, FLN1

• Tested Applications:

  WB, IHC-P, IF, Flow

• Protein ID:

  116241365

• Physical Properties:

  Liquid