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RYK Antibody

CAT: 0223-63-136Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-63-136Size:400 µL
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Background
RYK is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. A nine nucleotide insertion in some transcripts results in the SLG variant. It is not established whether this is a product of alternative splicing or a second gene, since evidence for a second gene or pseudogene on chromosome 17 exists.
NCBI Gene ID
6259
Swiss Prot
P34925
Accession Number
P34925
Host
Rabbit
Reactivity
Human
Immunogen
This RYK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 383-410 amino acids from the Central region of human RYK.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
68 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
RYK
NCBI Official Name
Tyrosine-protein kinase RYK
NCBI Organism
Homo sapiens
Background Reference 01
Trivier, E., et al., J. Biol. Chem. 277 (25) :23037-23043 (2002) .
Background Reference 02
Katso, R.M., et al., Mol. Cell. Biol. 19 (9) :6427-6440 (1999) .
Background Reference 03
Wang, X.C., et al., Mol. Med. 2 (2) :189-203 (1996) .
Background Reference 04
Tamagnone, L., et al., Oncogene 8 (7) :2009-2014 (1993) .
Other Product Names
Tyrosine-protein kinase RYK, RYK, JTK5A
Tested Applications
WB
Protein ID
1710811
Physical Properties
Liquid

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