ERBB4 Antibody

CAT: 0223-63-073Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-63-073Size:400 µL
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.
NCBI Gene ID
2066
Swiss Prot
Q15303
Accession Number
Q15303
Host
Rabbit
Reactivity
Human
Immunogen
This ERBB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1276-1308 amino acids from the C-terminal region of human ERBB4.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
147 kDa
Fragment
Rabbit Ig
Symbol
ERBB4
NCBI Official Name
Receptor tyrosine-protein kinase erbB-4
NCBI Organism
Homo sapiens
Background Reference 01
Cheng, Q.C., et al., J. Biol. Chem. 278 (40) :38421-38427 (2003) .
Background Reference 02
Komuro, A., et al., J. Biol. Chem. 278 (35) :33334-33341 (2003) .
Background Reference 03
Williams, E.E., et al., Cancer Lett. 192 (1) :67-74 (2003) .
Background Reference 04
Thomas, C.Y., et al., Int. J. Cancer 104 (1) :19-27 (2003) .
Other Product Names
Receptor tyrosine-protein kinase erbB-4, Proto-oncogene-like protein c-ErbB-4, Tyrosine kinase-type cell surface receptor HER4, p180erbB4, ERBB4 intracellular domain, 4ICD, E4ICD, s80HER4, ERBB4, HER4
Tested Applications
WB, IHC-P
Protein ID
3913590
Physical Properties
Liquid

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