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ERBB3 Antibody

CAT: 0223-13-331Size: 100 µLDry Ice: NoHazardous: No
CAT#:13-331Size:100 µL
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PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
NCBI Gene ID
2065
Swiss Prot
P21860
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 20-285 of human ERBB3 (NP_001973.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Growth Factors, Immunology, Signal Transduction
Purification
Affinity purification
Positive Control
Mouse skeletal muscle
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 200kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
ERBB3
Positive Control 2
Mouse lung
Positive Control 3
Rat skeletal muscle
NCBI Official Name
V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
NCBI Organism
Homo sapiens
Other Product Names
ERBB3, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian), HGNC:3431, ErbB-3, HER3, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3, erbB-3
Tested Applications
WB
Physical Properties
Liquid

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