ALK Antibody

• Background:

  ALK, a member of the insulin receptor subfamily of Tyr protein kinases, is an orphan receptor. It appears to play an important role in the normal development and function of the nervous system. This Type I membrane protein is expressed in brain and CNS and in the small intestine and testis, but not in normal lymphoid cells. A form of non-Hodgkin's lymphoma is characterized by a chromosomal translocation t (2;5) (p23; q35) that involves NPM1 and ALK. The protein contains 1 LDL-receptor class A domain and 2 putative MAM domains.

• NCBI Gene ID:

  238

• Swiss Prot:

  Q9UM73

• Accession Number:

  Q9UM73

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ALK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1591~1620 amino acids from the C-terminal region of human ALK.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Neuroscience

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  176 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For IHC-P starting dilution is: 1:50~100

• Symbol:

  ALK

• NCBI Official Name:

  ALK tyrosine kinase receptor

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Morris, S.W., et al., Oncogene 14 (18) :2175-2188 (1997) .

• Background Reference 02:

  Iwahara, T., et al., Oncogene 14 (4) :439-449 (1997) .

• Background Reference 03:

  Morris, S.W., et al., Science 263 (5151) :1281-1284 (1994) .

• Background Reference 04:

  Morris, S.W., et al., Oncogene 15, 2883-2883 (1997) .

• Other Product Names:

  ALK tyrosine kinase receptor, Anaplastic lymphoma kinase, CD246, ALK

• Tested Applications:

  IHC-P

• Protein ID:

  296439447

• Physical Properties:

  Liquid