ALK (phospho Tyr1096) Antibody

• Background:

  The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas (ALCLs) . The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain.

• NCBI Gene ID:

  238

• Swiss Prot:

  Q9UM73

• Accession Number:

  NP_004295.2

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  ALK (phospho Tyr1096) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 1096 (P-N-Y (p) -C-F) derived from Human ALK.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Phospho-Specific

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific peptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  Phospho-Specific

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  176 kDa

• Fragment:

  IgG

• Specificity:

  The antibody detects endogenous levels of ALK only when phosphorylated at tyrosine 1096.

• Symbol:

  Alk

• NCBI Official Name:

  Anaplastic lymphoma receptor tyrosine kinase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Morris S.W., Oncogene 14:2175-2188 (1997) .

• Background Reference 02:

  Morris S.W., Oncogene 15:2883-2883 (1997) .

• Background Reference 03:

  Iwahara T., Oncogene 14:439-449 (1997) .

• Other Product Names:

  ALK tyrosine kinase receptor, anaplastic lymphoma kinase, anaplastic lymphoma kinase (Ki-1), CD246; EC 2.7.10.1, kinase ALK

• Tested Applications:

  IHC

• Protein ID:

  110347475

• Physical Properties:

  Liquid