SPRY4 Antibody

• Background:

  SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. The protein is positioned upstream of RAS activation and impairs the formation of active GTP-RAS.

• NCBI Gene ID:

  81848

• Swiss Prot:

  Q9C004

• Accession Number:

  Q9C004

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This SPRY4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 270-301 amino acids from the C-terminal region of human SPRY4.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  33 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  SPRY4

• NCBI Official Name:

  Protein sprouty homolog 4

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Tsai CF, et al. (2008) Proteome Res

• Background Reference 02:

  Guo A, et al. (2008) Proc Natl Acad SciS105, 692-7

• Background Reference 03:

  Rikova K, et al. (2007) Cell 131, 1190-203

• Background Reference 04:

  Wolf-Yadlin A, Hautaniemi S, Lauffenburger DA, White FM (2007) Proc Natl Acad SciS104, 5860-5

• Other Product Names:

  Protein sprouty homolog 4, Spry-4, SPRY4

• Tested Applications:

  WB

• Protein ID:

  14916719

• Physical Properties:

  Liquid