Products for Research Use Only
RegisterLogin

PCSK9 Recombinant Protein

CAT: 0223-96-818Size: 0.05 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-96-818Size:0.05 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is also known as NARC1 (neural apoptosis regulated convertase), is a newly identified subtilase belonging to the peptidase S8 subfamily. Mouse PCSK9 is synthesized as a soluble zymogen, and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted active enzyme with a broad alkaline pH optimum. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3) .
CAS Number
9000-83-3
Swiss Prot
G3GTK5
Accession Number
G3GTK5
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Immunology
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
73 kDa
Applications Notes
This recombinant protein can be used for E, WB. For research use only.
NCBI Organism
Cricetulus griseus
Background Reference 01
Seidah NG, et al., Proc. Natl. Acad. Sci. U.S.A. 100 (3) : 928–33.
Background Reference 02
Abifadel, M. et al., 2003, Nat. Genet. 34: 154-156.
Background Reference 03
Dubuc G. et al., 2004, Arterioscler. Thromb. Vasc. Biol. 24 (8) : 1454–9.
Other Product Names
PCSK9, FH3, HCHOLA3, LDLCQ1, NARC1, PC9
Tested Applications
ELISA, WB
Species
Hamster
Physical Properties
Lyophilized

Related Products

CatalogName
96-589PCSK9 (D374Y) Recombinant Protein
42-479PCSK9 Antibody
42-463PPCSK9 Peptide
42-463PCSK9 Antibody
46-147PPCSK9 Peptide
62-831PCSK9 Antibody
62-832PCSK9 Antibody
42-479PPCSK9 Peptide
46-147PCSK9 Antibody
23-233PCSK9 Antibody

Alternative Products

CatalogName
OPCD06028-10UGPCSK9 Recombinant Protein
GWB-PS8774PCSK9 Human Recombinant Protein
MBS8249553-01Recombinant Human PCSK9 Protein
CRP2065-01Recombinant Mouse PCSK9 Protein
PX-P5124-01Human PCSK9 recombinant protein
TP727008Pcsk9 Mouse Recombinant Protein
GTR18906998PCSK9 (D374Y) Recombinant Protein

Popular Products