CD160 Antibody

• Background:

  CD160, also known as BY55, is a lipid-anchored cell membrane glycoprotein that contains one immunoglobulin-like domain (1) . It is expressed in small intestine, spleen and functional NK and T cytotoxic lymphocytes (1,2) . CD160 exists as a disulfide-linked homomultimer that functions as a receptor for MHC (major histocompatability complex) molecules and is thought to regulate the function of NK cells (2,3) . Additionally, CD160 interacts with TNFRSF14 and, via this interaction, is able to negatively regulate CD4+ T cell activation, indicating a role in immune system regulation (4) .

• NCBI Gene ID:

  11126

• Swiss Prot:

  O95971

• Accession Number:

  NP_008984

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  CD160 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1204 - K562 Cell Lysate

• Concentration:

  1 mg/mL

• Buffer:

  CD160 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  CD160 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  CD160 antibody is human and mouse reactive. Multiple isoforms of CD160 are known to exist.

• Symbol:

  CD160

• NCBI Official Name:

  CD160 molecule

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Anumanthan A, Bensussan A, Boumsell L, et al. Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes. J. Immunol. 1998; 161:2780-90.

• Background Reference 02:

  Agrawal S, Marquet J, Freeman GJ, et al. Cutting edge: MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells. J. Immunol. 1999; 162:1223-6.

• Background Reference 03:

  Le Bouteiller P, Tabiasco J, Polgar B, et al. CD160: a unique activating NK cell receptor. Immunol. Lett. 2011;138:93-6

• Background Reference 04:

  Chabot S, Jabrane-Ferrat N, Bigot K, et al. A novel antiangiogenic and vascular normalization therapy targeted against human CD160 receptor. J. Exp. Med. 2011; 208:973-86.

• Other Product Names:

  CD160 Antibody : NK1, BY55, NK28, CD160 antigen, Natural killer cell receptor BY55

• Tested Applications:

  ELISA, WB, IF

• Protein ID:

  5901910

• Physical Properties:

  Liquid