CD160 Antibody

• Background :

  CD160, also known as BY55, is a lipid-anchored cell membrane glycoprotein that contains one immunoglobulin-like domain (1) . It is expressed in small intestine, spleen and functional NK and T cytotoxic lymphocytes (1,2) . CD160 exists as a disulfide-linked homomultimer that functions as a receptor for MHC (major histocompatability complex) molecules and is thought to regulate the function of NK cells (2,3) . Additionally, CD160 interacts with TNFRSF14 and, via this interaction, is able to negatively regulate CD4+ T cell activation, indicating a role in immune system regulation (4) .

• NCBI Gene ID :

  11126

• Swiss Prot :

  O95971

• Accession Number :

  NP_008984

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Immunology

• Purification :

  CD160 Antibody is affinity chromatography purified via peptide column.

• Positive Control :

  Cat. No. 1204 - K562 Cell Lysate

• Concentration :

  1 mg/mL

• Buffer :

  CD160 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  CD160 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment :

  IgG

• Specificity :

  CD160 antibody is human and mouse reactive. Multiple isoforms of CD160 are known to exist.

• Symbol :

  CD160

• NCBI Official Name :

  CD160 molecule

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Anumanthan A, Bensussan A, Boumsell L, et al. Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes. J. Immunol. 1998; 161:2780-90.

• Background Reference 02 :

  Agrawal S, Marquet J, Freeman GJ, et al. Cutting edge: MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells. J. Immunol. 1999; 162:1223-6.

• Background Reference 03 :

  Le Bouteiller P, Tabiasco J, Polgar B, et al. CD160: a unique activating NK cell receptor. Immunol. Lett. 2011;138:93-6

• Background Reference 04 :

  Chabot S, Jabrane-Ferrat N, Bigot K, et al. A novel antiangiogenic and vascular normalization therapy targeted against human CD160 receptor. J. Exp. Med. 2011; 208:973-86.

• Other Product Names :

  CD160 Antibody : NK1, BY55, NK28, CD160 antigen, Natural killer cell receptor BY55

• Tested Applications :

  ELISA, WB, IF

• Protein ID :

  5901910

• Physical Properties :

  Liquid