PHB2 Antibody

• Background:

  PHB2 acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. It functions as an estrogen receptor (ER) -selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. It competes with NCOA1 for modulation of ER transcriptional activity and is probably involved in regulating mitochondrial respiration activity and in aging.

• NCBI Gene ID:

  11331

• Swiss Prot:

  Q99623

• Accession Number:

  Q99623

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This PHB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-134 amino acids from human PHB2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Chicken, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  33 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  PHB2

• NCBI Official Name:

  Prohibitin-2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Takata, H., Curr. Biol. 17 (15), 1356-1361 (2007)

• Background Reference 02:

  Kasashima, K., J. Biol. Chem. 281 (47), 36401-36410 (2006)

• Other Product Names:

  Prohibitin-2, B-cell receptor-associated protein BAP37, D-prohibitin, Repressor of estrogen receptor activity, PHB2 {ECO:0000312|EMBL:AAH147661, ECO:0000312|HGNC:HGNC:30306}

• Tested Applications:

  WB, IHC-P

• Protein ID:

  74752151

• Physical Properties:

  Liquid