PHB1 Antibody

• Background:

  Prohibitin is an evolutionarily conserved protein that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region.

• NCBI Gene ID:

  5245

• Swiss Prot:

  P35232

• Accession Number:

  P35232

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PHB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 182-211 amino acids from the C-terminal region of human PHB1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Obesity

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  30 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  PHB

• NCBI Official Name:

  Prohibitin

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Gregory-Bass, R.C., Int. J. Cancer 122 (9), 1923-1930 (2008)

• Background Reference 02:

  Ross, J.A., J. Biol. Chem. 283 (8), 4699-4713 (2008)

• Background Reference 03:

  White, J.J., Genomics 11 (1), 228-230 (1991)

• Other Product Names:

  Prohibitin, PHB

• Tested Applications:

  WB

• Protein ID:

  464371

• Physical Properties:

  Liquid