Aurora-B Antibody

• Background:

  Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases associate with microtubules during chromosome movement and segregation. STK12 (Aurora kinase B) localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers, and Aurora kinase A localizes to centrosomes

• NCBI Gene ID:

  9212

• Swiss Prot:

  Q96GD4

• Accession Number:

  Q96GD4

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This Aurora-B (ARK/STK12) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 283-313 amino acids from the Central region of human Aurora-B (ARK/STK12) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  39 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  AURKB

• NCBI Official Name:

  Aurora kinase B

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kimura, M., et al., Biochem. Biophys. Res. Commun. 316 (3) :930-936 (2004) .

• Background Reference 02:

  Yasui, Y., et al., J. Biol. Chem. 279 (13) :12997-13003 (2004) .

• Background Reference 03:

  Lampson, M.A., et al., Nat. Cell Biol. 6 (3) :232-237 (2004) .

• Background Reference 04:

  Wheatley, S.P., et al., J. Biol. Chem. 279 (7) :5655-5660 (2004) .

• Other Product Names:

  Aurora kinase B, Aurora 1, Aurora- and IPL1-like midbody-associated protein 1, AIM-1, Aurora/IPL1-related kinase 2, ARK-2, Aurora-related kinase 2, STK-1, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 5, Serine/threonine-protein kinase aurora-B, AURKB, AIK2, AIM1, AIRK2, ARK2, STK1, STK12, STK5

• Tested Applications:

  WB, IHC-P

• Protein ID:

  317373473

• Physical Properties:

  Liquid