Aurora-C Antibody

• Background:

  Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases, members of the Ser/Thr protein kinase family, associate with microtubules during chromosome movement and segregation. Aurora kinase C may play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. This protein is localized to centrosome from anaphase to cytokinesis. Expression is limited to testis in normal cells. Elevated expression levels are seen only in a subset of cancer cells such as HepG2, HuH7 and HeLa cells. Aurora-C expression is maximum at M phase.

• NCBI Gene ID:

  6795

• Swiss Prot:

  Q9UQB9

• Accession Number:

  Q9UQB9

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This Aurora-C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-145 amino acids from the Central region of human Aurora-C.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  36 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  AURKC

• NCBI Official Name:

  Aurora kinase C

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kimura, M., et al., J. Biol. Chem. 274 (11) :7334-7340 (1999) .

• Background Reference 02:

  Tseng, T.C., et al., DNA Cell Biol. 17 (10) :823-833 (1998) .

• Background Reference 03:

  Bernard, M., et al., Genomics 53 (3) :406-409 (1998) .

• Other Product Names:

  Aurora kinase C, Aurora 3, Aurora/IPL1-related kinase 3, ARK-3, Aurora-related kinase 3, Aurora/IPL1/Eg2 protein 2, Serine/threonine-protein kinase 13, Serine/threonine-protein kinase aurora-C, AURKC, AIE2, AIK3, AIRK3, ARK3, STK13

• Tested Applications:

  WB

• Protein ID:

  27805738

• Physical Properties:

  Liquid