CIDE-B Antibody

CAT: 0223-2319-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-2319-01Size:0.02 mg
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Background
CIDE-B Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. DFF45/ICAD has been identified as inhibitor of caspase activated DNase DFF40/CAD. DFF45 related proteins CIDE-A and CIDE-B (for cell death-inducing DFF-like effector A and B) were recently identified. CIDE contains a new type of domain termed CIDE-N, which has high homology with the regulatory domains of DFF45/ICAD and DFF40/CAD. Expression of CIDE-B induces apoptosis, which is inhibited by DFF45. CIDE-B is a DFF45-inhibitable effector that promotes cell death and DNA fragmentation. CIDE-B is expressed mainly in liver and at lower levels in spleen, kidney, peripheral blood lymphocytes and bone marrow.
NCBI Gene ID
27141
Swiss Prot
Q9UHD4
Accession Number
AF218586
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis
Purification
CIDE-B Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1408 - Mouse Small Intestine Tissue Lysate
Concentration
1 mg/ml
Buffer
CIDE-B Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
CIDE-B antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
CIDE-B antibody has no cross activity to CIDE-A.
Symbol
CIDEB
Positive Control 2
Cat. No. 1308 - Human Small Intestine Tissue Lysate
Positive Control 3
Cat. No. 11-801 - Human Small Intestine Tissue Slide
NCBI Official Name
Cell death-inducing DFFA-like effector b
NCBI Organism
Homo sapiens
Background Reference 01
Inohara N, Koseki T, Chen S, et al. CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor. EMBO J. 1998; 17:2526-33
Background Reference 02
Inohara N, Koseki T, Chen S, et al. Identification of regulatory and catalytic domains in the apoptosis nuclease DFF40/CAD. J. Biol. Chem.1999; 274:270-4.
Other Product Names
CIDE-B Antibody: CIDE-B, AI790179, 1110030C18Rik, Cell death activator CIDE-B, Cell death-inducing DFFA-like effector B
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
6746626
Physical Properties
Liquid

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