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SPHK2 Antibody

CAT: 0223-62-750Size: 200 µLDry Ice: NoHazardous: No
CAT#:0223-62-750Size:200 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Sphingosine Kinase (SphK) catalyzes the phosphorylation of the lipid sphingosine, creating the bioactive lipid sphingosine-1-phosphate (S1P) . S1P subsequently signals through cell surface G protein-coupled receptors, as well as intracellularly, to modulate cell proliferation, survival, motility and differentiation. SphK is an important signaling enzyme which is activated by diverse agents, including growth factors that signal through receptor tyrosine kinases, agents activating G protein-coupled receptors, and immunoglobulin receptors. Two SphK isotypes, SphK-1 and SphK-2, have been cloned, and both isotypes are ubiquitously expressed. SphK-1 has been shown to mediate cell growth, prevention of apoptosis, and cellular transformation, and is upregulated in a variety of human tumors. In contrast, SphK-2 increases apoptosis, and may be responsible for phosphorylating and activating the immunosuppressive drug FTY720.
NCBI Gene ID
56848
Swiss Prot
Q9NRA0
Accession Number
Q9NRA0
Host
Rabbit
Reactivity
Human
Immunogen
This SPHK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 590-620 amino acids from the C-terminal region of human SPHK2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Obesity, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
69 kDa
Fragment
Rabbit Ig
Symbol
SPHK2
NCBI Official Name
Sphingosine kinase 2
NCBI Organism
Homo sapiens
Background Reference 01
Shu, X., et al., Mol. Cell. Biol. 22 (22) :7758-7768 (2002) .
Background Reference 02
Xia, P., et al., J. Biol. Chem. 277 (10) :7996-8003 (2002) .
Background Reference 03
Liu, H., et al., J. Biol. Chem. 275 (26) :19513-19520 (2000) .
Background Reference 04
Shutler, G., et al., Genomics 34 (3) :334-339 (1996) .
Other Product Names
Sphingosine kinase 2, SK 2, SPK 2, SPHK2
Tested Applications
WB, IHC-P
Protein ID
22001996
Physical Properties
Liquid

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