HMGB2 Antibody

• Background :

  HMGB2 is a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V (D) J recombination.

• NCBI Gene ID :

  3148

• Swiss Prot :

  P26583

• Accession Number :

  P26583

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This HMGB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 92-118 amino acids from the Central region of human HMGB2.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Other

• Purification :

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Bovine, Pig, Rat

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  24 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  HMGB2

• NCBI Official Name :

  High mobility group protein B2

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Majumdar A., Brown D. 19:6643-6643 (1991)

• Background Reference 02 :

  Shirakawa H., Yoshida M.J.. 267:6641-6645 (1992)

• Background Reference 03 :

  Alexandre S., Li W.W.Nucleic Acids Res. 20:6413-6413 (1992)

• Background Reference 04 :

  Fan Z., Beresford P.J.Mol. Cell. Biol. 22:2810-2820 (2002)

• Other Product Names :

  High mobility group protein B2, High mobility group protein 2, HMG-2, HMGB2, HMG2

• Tested Applications :

  WB

• Protein ID :

  123374

• Physical Properties :

  Liquid