ERN2 Antibody

• Background:

  ERN2 induces translational repression through 28S ribosomal RNA cleavage in response to endoplasmic reticulum (ER) stress. This pro-apoptotic appears to play no role in the unfolded-protein response, unlike closely related proteins. Overexpression of ERN2 activates both BiP and CHOP expression, and also leads to the development of programmed cell death. It has been suggested that Ern2 plays a role in multiple facets of the ER stress response in mammalian cells.

• NCBI Gene ID:

  10595

• Swiss Prot:

  Q76MJ5

• Accession Number:

  Q76MJ5

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ERN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-72 amino acids from the N-terminal region of human ERN2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  102 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  ERN2

• NCBI Official Name:

  Serine/threonine-protein kinase/endoribonuclease IRE2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Iwawaki, T., et al., Nat. Cell Biol. 3 (2) :158-164 (2001) .

• Background Reference 02:

  Niwa, M., et al., Cell 99 (7) :691-702 (1999) .

• Background Reference 03:

  Wang, X.Z., et al., EMBO J. 17 (19) :5708-5717 (1998) .

• Other Product Names:

  HGNC:16942

• Tested Applications:

  WB

• Protein ID:

  327478597

• Physical Properties:

  Liquid