Mouse Ern1 Antibody

CAT: 0223-57-590Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-57-590Size:400 µL
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Background
Ern1 senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.
NCBI Gene ID
78943
Swiss Prot
Q9EQY0
Accession Number
Q9EQY0
Host
Rabbit
Reactivity
Mouse
Immunogen
This Mouse Ern1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 827-855 amino acids from the C-terminal region of mouse Ern1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
110 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
Ern1
NCBI Official Name
Serine/threonine-protein kinase/endoribonuclease IRE1
NCBI Organism
Mus musculus
Background Reference 01
Li, H., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (37) :16113-16118 (2010)
Background Reference 02
Auf, G., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (35) :15553-15558 (2010)
Background Reference 03
Oikawa, D., et al. FEBS Lett. 584 (5) :1066-1070 (2010)
Background Reference 04
Yang, L., et al. PLoS ONE (7), E11621 (2010) :
Other Product Names
Serine/threonine-protein kinase/endoribonuclease IRE1, Endoplasmic reticulum-to-nucleus signaling 1, Inositol-requiring protein 1, Ire1-alpha, IRE1a, Serine/threonine-protein kinase, Endoribonuclease, 3126-, Ern1 {ECO:0000312|MGI:MGI:1930134}
Tested Applications
WB
Physical Properties
Liquid

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