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NAGK Antibody

CAT: 0223-62-644Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-62-644Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
N-acetylglucosamine kinase (NAGK) converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. NAGK belongs to the group of N-acetylhexosamine kinases and is a prominent salvage enzyme of amino sugar metabolism in mammals. The predicted 344-amino acid NAGK protein contains the 5 sequence motifs necessary for the binding of ATP by sugar kinases. NAGK shares 91.6% amino acid similarity with mouse Nagk, for which enzyme activity is detectable in all mouse tissues examined, with highest enzymatic activity in testis. It is hypothesized that NAGK has a general role in the catabolic pathways of GlcNAc as well as of ManNAc.
NCBI Gene ID
55577
Swiss Prot
Q9UJ70
Accession Number
Q9UJ70
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This NAGK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 300-330 amino acids from the C-terminal region of human NAGK.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Obesity, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
37 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
NAGK
NCBI Official Name
N-acetyl-D-glucosamine kinase
NCBI Organism
Homo sapiens
Background Reference 01
Hinderlich, S., et al., Eur. J. Biochem. 267 (11) :3301-3308 (2000) .
Background Reference 02
Lowes, W., et al., Biochim. Biophys. Acta 1379 (1) :134-142 (1998) .
Background Reference 03
Weidanz, J.A., et al., Br. J. Haematol. 95 (4) :645-653 (1996) .
Other Product Names
N-acetyl-D-glucosamine kinase, N-acetylglucosamine kinase, GlcNAc kinase, NAGK
Tested Applications
WB
Protein ID
24638065
Physical Properties
Liquid

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