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GRK5 Antibody

CAT: 0223-62-585Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-62-585Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK) .
NCBI Gene ID
2869
Swiss Prot
P34947
Accession Number
P34947
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This GRK5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 559-590 amino acids from the C-terminal region of human GRK5.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein G column, followed by dialysis against PBS.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
68 kDa
Fragment
Rabbit Ig
Symbol
GRK5
NCBI Official Name
G protein-coupled receptor kinase 5
NCBI Organism
Homo sapiens
Background Reference 01
Pronin, A.N., et al., J. Biol. Chem. 275 (34) :26515-26522 (2000) .
Background Reference 02
Pronin, A.N., et al., J. Biol. Chem. 273 (47) :31510-31518 (1998) .
Background Reference 03
Nagayama, Y., et al., J. Biol. Chem. 271 (17) :10143-10148 (1996) .
Background Reference 04
Kunapuli, P., et al., J. Biol. Chem. 269 (2) :1099-1105 (1994) .
Other Product Names
G protein-coupled receptor kinase 5, G protein-coupled receptor kinase GRK5, GRK5, GPRK5
Tested Applications
WB, IHC-P
Protein ID
462203
Physical Properties
Liquid

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