GRK1 Antibody

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK) . The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK) .

6011

Q15835

Q15835

Human, Mouse

This GRK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 520-550 amino acids from the C-terminal region of human GRK1.

Unconjugated

Primary Antibodies

Neuroscience, Signal Transduction

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Batch dependent

Supplied in PBS with 0.09% (W/V) sodium azide.

None

Blue Ice

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

64 kDa

Rabbit Ig

GRK1

Rhodopsin kinase

Homo sapiens

Zhao, X., et al., J. Biol. Chem. 273 (9) :5124-5131 (1998) .

Zhao, X., et al., Vis. Neurosci. 14 (2) :225-232 (1997) .

Yamamoto, S., et al., Nat. Genet. 15 (2) :175-178 (1997) .

Khani, S.C., et al., Genomics 35 (3) :571-576 (1996) .

Rhodopsin kinase, RK, G protein-coupled receptor kinase 1, GRK1, RHOK

WB, IHC-P

2833269