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GRK6 Antibody

CAT: 0223-7641-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7641-01Size:0.02 mg
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Background
The G protein–coupled receptor kinases (GRKs) are a versatile family of kinases that play a critical role in cancer metastasis through their regulation of G-protein coupled receptors (GPCRs) involved in growth factor mediated cell migration (1,2) . Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state (1) . GRK6 is one of 7 members of the GRK serine/threonine kinase subfamily, which has been shown to modulate the Wnt signaling pathway via phosphorylation of LRP6 (3,4), and the insulin-like growth factor signaling pathway (4) . GRK6 may also play a role in immune system function (5) .
NCBI Gene ID
2870
Swiss Prot
P43250
Accession Number
NP_001004106
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
GRK6 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1468 - Rat Small Intestine Tissue Lysate
Concentration
1 mg/mL
Buffer
GRK6 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
GRK6 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
GRK6 antibody is human, mouse and rat reactive. Multiple isoforms of GRK6 are known to exist. This antibody is predicted to not cross-react with other members of the GRK protein family.
Symbol
GRK6
Positive Control 2
Cat. No. 11-801 - Human Small Intestine Tissue Slide
NCBI Official Name
G protein-coupled receptor kinase 6
NCBI Organism
Homo sapiens
Background Reference 01
Inglese J, Freedman NJ, Koch WJ, et al. Structure and mechanism of the G protein-coupled receptor kinases. J. Biol. Chem. 1993; 268:23735-8.
Background Reference 02
Raghuwanshi SK, Smith N, Rivers EJ, et al. G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis. J. Immunol. 2013; 190:5329-36.
Background Reference 03
Benovic JL and Gomez J. Molecular cloning and expression of GRK6. A new member of the G protein-coupled receptor kinase family. J. Biol. Chem. 1993; 268:19521-7.
Background Reference 04
Chen M, Philipp M, Wang J, et al. G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway. J. Biol. Chem. 2009; 284:35040-8.
Other Product Names
GRK6 Antibody: GPRK6, GPRK6, G protein-coupled receptor kinase 6, G protein-coupled receptor kinase GRK6
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
51896039
Physical Properties
Liquid

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