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C-rel Antibody

CAT: 0223-62-252Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-62-252Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Nuclear factor (NF) -kappa B is a sequence specific transcriptional activator that binds to the intronic enhancer of kappa light chain gene in B lymphocytes. NF-kB regulates the expression of a wide variety of genes that involved in apoptosis, viral life cycle, tumorigenesis, autoimmune diseases and inflammation. NF-kB is a heterodimer of members of the rel family of proteins such as p50, p65, and c-rel. In most cells, inhibitory IkB proteins sequester NF-kB/Rel in the cytoplasm. Cellular stimulation precipitates degradation of IkB and modification of NF-kB/Rel proteins, permitting translocation of NF-kB/Rel (c-Rel and RelA) to the nucleus for action on target genes. The important role of c-Rel in B-cell development, growth, and survival has been intensively studied, as well as its function in differentiation and lymphopoiesis (particularly lymphoid cancer) .
NCBI Gene ID
5966
Swiss Prot
Q04864
Accession Number
Q04864
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This C-rel (NFkB) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 586-619 amino acids from the C-terminal region of human C-rel (NFkB) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
69 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
REL
NCBI Official Name
Proto-oncogene c-Rel
NCBI Organism
Homo sapiens
Background Reference 01
Jain, A., et al., J. Clin. Invest. 114 (11) :1593-1602 (2004) .
Background Reference 02
Xiao, Q., et al., Appl. Immunohistochem. Mol. Morphol. 12 (3) :211-215 (2004) .
Background Reference 03
Houldsworth, J., et al., Blood 103 (5) :1862-1868 (2004) .
Background Reference 04
Phelps, C.B., et al., Oncogene 23 (6) :1229-1238 (2004) .
Other Product Names
Proto-oncogene c-Rel, REL
Tested Applications
WB
Protein ID
548720
Physical Properties
Liquid

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