MTM1 Antibody

CAT: 0223-62-480Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-62-480Size:400 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
MTM1 is a member of a protein family that encodes tyrosine phosphatases. Myotubularin is required for muscle cell differentiation and mutations in MTM1 have been identified as being responsible for X-linked myotubular myopathy. MTM1 is a potent phosphatidylinositol 3-phosphate phosphatase (PI (3) P) . Mutations in the MTM1 gene that cause human myotubular myopathy dramatically reduce the ability of the phosphatase to dephosphorylate PI (3) P. The findings provided evidence that myotubularin exerts its effects during myogenesis by regulating the cellular levels of the inositol lipid PI (3) P.
NCBI Gene ID
4534
Swiss Prot
Q13496
Accession Number
Q13496
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This MTM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 566-594 amino acids from the C-terminal region of human MTM1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
70 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
MTM1
NCBI Official Name
Myotubularin
NCBI Organism
Homo sapiens
Background Reference 01
Nandurkar, H.H., et al., Proc. Natl. Acad. Sci. U.S.A. 100 (15) :8660-8665 (2003) .
Background Reference 02
Biancalana, V., et al., Hum. Genet. 112 (2) :135-142 (2003) .
Background Reference 03
Wishart, M.J., et al., Trends Cell Biol. 12 (12) :579-585 (2002) .
Background Reference 04
Herman, G.E., et al., Hum. Mutat. 19 (2) :114-121 (2002) .
Other Product Names
Myotubularin, Phosphatidylinositol-3,5-bisphosphate 3-phosphatase, Phosphatidylinositol-3-phosphate phosphatase, MTM1, CG2
Tested Applications
WB
Protein ID
2851537
Physical Properties
Liquid

Related Products

CatalogName
45-910PMTM1 Peptide
45-911MTMR1 Antibody
29-705MTMR1 Antibody
45-911PMTMR1 Peptide
64-160WAS Antibody
60-596WAS Antibody
13-349WAS Antibody
63-408DGKB Antibody
63-412AK5 Antibody
63-420HK3 Antibody

Alternative Products

CatalogName
MBS7116659-01MTM1 Antibody

Popular Products