MTM1 Antibody

• Background:

  MTM1 is a member of a protein family that encodes tyrosine phosphatases. Myotubularin is required for muscle cell differentiation and mutations in MTM1 have been identified as being responsible for X-linked myotubular myopathy. MTM1 is a potent phosphatidylinositol 3-phosphate phosphatase (PI (3) P) . Mutations in the MTM1 gene that cause human myotubular myopathy dramatically reduce the ability of the phosphatase to dephosphorylate PI (3) P. The findings provided evidence that myotubularin exerts its effects during myogenesis by regulating the cellular levels of the inositol lipid PI (3) P.

• NCBI Gene ID:

  4534

• Swiss Prot:

  Q13496

• Accession Number:

  Q13496

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This MTM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 566-594 amino acids from the C-terminal region of human MTM1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  70 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  MTM1

• NCBI Official Name:

  Myotubularin

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Nandurkar, H.H., et al., Proc. Natl. Acad. Sci. U.S.A. 100 (15) :8660-8665 (2003) .

• Background Reference 02:

  Biancalana, V., et al., Hum. Genet. 112 (2) :135-142 (2003) .

• Background Reference 03:

  Wishart, M.J., et al., Trends Cell Biol. 12 (12) :579-585 (2002) .

• Background Reference 04:

  Herman, G.E., et al., Hum. Mutat. 19 (2) :114-121 (2002) .

• Other Product Names:

  Myotubularin, Phosphatidylinositol-3,5-bisphosphate 3-phosphatase, Phosphatidylinositol-3-phosphate phosphatase, MTM1, CG2

• Tested Applications:

  WB

• Protein ID:

  2851537

• Physical Properties:

  Liquid