TROP2 Antibody

• Background:

  TROP2 is a carcinoma-associated antigen defined by the monoclonal antibody GA733. This antigen is a member of a family including at least two type I membrane proteins. It transduces an intracellular calcium signal and acts as a cell surface receptor. Mutations of its gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.

• NCBI Gene ID:

  4070

• Swiss Prot:

  P09758

• Accession Number:

  P09758

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This TROP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 162-190 amino acids from the Central region of human TROP2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  36 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  TACSTD2

• NCBI Official Name:

  Tumor-associated calcium signal transducer 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Goldstein, A.S., Proc. Natl. Acad. Sci. U.S.A. 105 (52), 20882-20887 (2008)

• Other Product Names:

  Tumor-associated calcium signal transducer 2, Cell surface glycoprotein Trop-2, Membrane component chromosome 1 surface marker 1, Pancreatic carcinoma marker protein GA733-1, TACSTD2, GA733-1, M1S1, TROP2

• Tested Applications:

  WB, IHC-P

• Protein ID:

  160113102

• Physical Properties:

  Liquid