PRELP Antibody

• Background:

  PRELP is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage.

• NCBI Gene ID:

  5549

• Swiss Prot:

  P51888

• Accession Number:

  P51888

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PRELP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 257-286 amino acids from the C-terminal region of human PRELP.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  44 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  PRELP

• NCBI Official Name:

  Prolargin

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Grover, J., Matrix Biol. 26 (2), 140-143 (2007)

• Background Reference 02:

  Johnson, J.M., Mol. Vis. 12, 1057-1066 (2006)

• Background Reference 03:

  Lewis, M., Ageing Res. Rev. (1), 95-105 (2003)

• Other Product Names:

  Prolargin, Proline-arginine-rich end leucine-rich repeat protein, PRELP, SLRR2A

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  1709586

• Physical Properties:

  Liquid