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Prolargin Antibody / PRELP

CAT: 0800-RQ8143Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ8143Size:100 µg
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Description
Prolargin is a protein that in humans is encoded by the PRELP gene. The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Flow cytometry: 1-3ug/million cells, Direct ELISA: 0.1-0.5 µg/mL
UniProt
P51888
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
E. coli-derived recombinant human protein (amino acids I69-R353) was used as the immunogen for the Prolargin antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, FACS, Direct ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the Prolargin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Prolargin antibody is available for research use only.
Storage Conditions
After reconstitution, the Prolargin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the Prolargin antibody should be determined by the researcher.
Image Legend
Flow cytometry testing of fixed and permeabilized human RT4 cells with Prolargin antibody at 1ug/million cells (blocked with goat sera) ; Red=cells alone, Green=isotype control, Blue= Prolargin antibody.

UniProtKB · P51888

Prolargin

PRELP_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P51888
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PRELP
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q6FG38
Protein keywords

Technical term

Direct protein sequencingProteomics identificationReference proteome

PTM

Disulfide bondGlycoproteinHeparan sulfateProteoglycan

Cellular component

Extracellular matrixSecreted

Molecular function

Heparin-binding

Domain

Leucine-rich repeatRepeatSignal

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MBS1484652-01Recombinant Mouse Prolargin (Prelp)
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MBS954051-01Recombinant Human Prolargin (PRELP)
MBS9340255-01Bovine Prolargin, PRELP ELISA Kit
G1776Prolargin (PRELP) Mouse ELISA Kit
G1775Prolargin (PRELP) Human ELISA Kit
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