SOST Antibody

• Background :

  Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of the sclerostin gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.

• NCBI Gene ID :

  50964

• Swiss Prot :

  Q9BQB4

• Accession Number :

  Q9BQB4

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This SOST antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-163 amino acids from the Central region of human SOST.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cell Cycle, Signal Transduction

• Purification :

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  24 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  SOST

• NCBI Official Name :

  Sclerostin

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Semenov, M.V., J. Biol. Chem. 281 (50), 38276-38284 (2006)

• Background Reference 02 :

  Ellies, D.L., J. Bone Miner. Res. 21 (11), 1738-1749 (2006)

• Background Reference 03 :

  Balemans, W., Musculoskelet Neuronal Interact (4), 355-356 (2006)

• Background Reference 04 :

  Gardner, J.C., J. Clin. Endocrinol. Metab. 90 (12), 6392-6395 (2005)

• Other Product Names :

  Sclerostin, SOST

• Tested Applications :

  WB, IHC-P

• Protein ID :

  20140220

• Physical Properties :

  Liquid