WISP2 Antibody

• Background:

  Wisp2 a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. Wisp2 lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.

• NCBI Gene ID:

  8839

• Swiss Prot:

  O76076

• Accession Number:

  O76076

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This WISP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 87-116 amino acids from the Central region of human WISP2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  27 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  WISP2

• NCBI Official Name:

  WNT1-inducible-signaling pathway protein 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Clark, H.F., et al., Genome Res. 13 (10) :2265-2270 (2003) . Banerjee, S., et al., Neoplasia 5 (1) :63-73 (2003) . Kumar, S., et al., J. Biol. Chem. 274 (24) :17123-17131 (1999) . Pennica, D., et al., Proc. Natl. Acad. Sci. U.S.A. 95 (25) :14717-14722 (1998) . Saxena, N., et al., Mol. Cell. Biochem. 228 (1-2), 99-104 (2001) .

• Other Product Names:

  WNT1-inducible-signaling pathway protein 2, WISP-2, CCN family member 5, Connective tissue growth factor-like protein, CTGF-L, Connective tissue growth factor-related protein 58, WISP2, CCN5, CT58, CTGFL

• Tested Applications:

  WB, IHC-P

• Physical Properties:

  Liquid