WISP2 Antibody

CAT: 0223-62-200Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-62-200Size:400 µL
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Background
Wisp2 a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. Wisp2 lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.
NCBI Gene ID
8839
Swiss Prot
O76076
Accession Number
O76076
Host
Rabbit
Reactivity
Human
Immunogen
This WISP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 87-116 amino acids from the Central region of human WISP2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
27 kDa
Fragment
Rabbit Ig
Symbol
WISP2
NCBI Official Name
WNT1-inducible-signaling pathway protein 2
NCBI Organism
Homo sapiens
Background Reference 01
Clark, H.F., et al., Genome Res. 13 (10) :2265-2270 (2003) . Banerjee, S., et al., Neoplasia 5 (1) :63-73 (2003) . Kumar, S., et al., J. Biol. Chem. 274 (24) :17123-17131 (1999) . Pennica, D., et al., Proc. Natl. Acad. Sci. U.S.A. 95 (25) :14717-14722 (1998) . Saxena, N., et al., Mol. Cell. Biochem. 228 (1-2), 99-104 (2001) .
Other Product Names
WNT1-inducible-signaling pathway protein 2, WISP-2, CCN family member 5, Connective tissue growth factor-like protein, CTGF-L, Connective tissue growth factor-related protein 58, WISP2, CCN5, CT58, CTGFL
Tested Applications
WB, IHC-P
Physical Properties
Liquid

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