WISP3 Antibody

• Background:

  WISP3 is a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. WISP3 is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of the WISP3 gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis.

• NCBI Gene ID:

  8838

• Swiss Prot:

  O95389

• Accession Number:

  O95389

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This WISP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 305-335 amino acids from the Central region of human WISP3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  39 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  WISP3

• NCBI Official Name:

  WNT1-inducible-signaling pathway protein 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Clark, H.F., et al., Genome Res. 13 (10) :2265-2270 (2003) .

• Background Reference 02:

  Tanaka, S., et al., Gastroenterology 123 (1) :392-393 (2002) .

• Background Reference 03:

  Kleer, C.G., et al., Oncogene 21 (20) :3172-3180 (2002) .

• Background Reference 04:

  Hurvitz, J.R., et al., Nat. Genet. 23 (1) :94-98 (1999) .

• Other Product Names:

  WNT1-inducible-signaling pathway protein 3, WISP-3, CCN family member 6, WISP3, CCN6

• Tested Applications:

  WB, IHC-P

• Physical Properties:

  Liquid