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WISP3 Antibody

CAT: 0223-62-201Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-62-201Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
WISP3 is a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. WISP3 is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of the WISP3 gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis.
NCBI Gene ID
8838
Swiss Prot
O95389
Accession Number
O95389
Host
Rabbit
Reactivity
Human
Immunogen
This WISP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 305-335 amino acids from the Central region of human WISP3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
39 kDa
Fragment
Rabbit Ig
Symbol
WISP3
NCBI Official Name
WNT1-inducible-signaling pathway protein 3
NCBI Organism
Homo sapiens
Background Reference 01
Clark, H.F., et al., Genome Res. 13 (10) :2265-2270 (2003) .
Background Reference 02
Tanaka, S., et al., Gastroenterology 123 (1) :392-393 (2002) .
Background Reference 03
Kleer, C.G., et al., Oncogene 21 (20) :3172-3180 (2002) .
Background Reference 04
Hurvitz, J.R., et al., Nat. Genet. 23 (1) :94-98 (1999) .
Other Product Names
WNT1-inducible-signaling pathway protein 3, WISP-3, CCN family member 6, WISP3, CCN6
Tested Applications
WB, IHC-P
Physical Properties
Liquid

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