WISP1 Antibody

CAT: 0223-62-199Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-62-199Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Wisp1 is a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. Wisp1 may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level.
NCBI Gene ID
8840
Swiss Prot
O95388
Accession Number
O95388
Host
Rabbit
Reactivity
Human
Immunogen
This WISP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 171-200 amino acids from the Central region of human WISP1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
40 kDa
Fragment
Rabbit Ig
Symbol
WISP1
NCBI Official Name
WNT1-inducible-signaling pathway protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Hocevar, B.A., et al., EMBO J. 22 (12) :3084-3094 (2003) .
Background Reference 02
Tanaka, S., et al., Hepatology 37 (5) :1122-1129 (2003) .
Background Reference 03
Soon, L.L., et al., J. Biol. Chem. 278 (13) :11465-11470 (2003) .
Background Reference 04
Su, F., et al., Genes Dev. 16 (1) :46-57 (2002) .
Other Product Names
WNT1-inducible-signaling pathway protein 1, WISP-1, CCN family member 4, Wnt-1-induced secreted protein, WISP1, CCN4
Tested Applications
WB, IHC-P
Physical Properties
Liquid

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