WISP3 Antibody

CAT: 0223-15-742Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-15-742Size:100 µL
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Background
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of this gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis. Multiple transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
8838
Swiss Prot
O95389
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 42-260 of human WISP3 (NP_937882.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Growth Factors, Immunology, Stem Cell
Purification
Affinity purification
Positive Control
293T
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 41kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
WISP3
Positive Control 2
HT-29
Positive Control 3
DU145
Positive Control 4
HepG2
Positive Control 5
Mouse brain
Positive Control 6
Rat brain
NCBI Official Name
WNT1 inducible signaling pathway protein 3
NCBI Organism
Homo sapiens
Other Product Names
WISP3, CCN family member 6, CCN6, PPD, LIBC, PPAC, WISP-3
Tested Applications
WB
Physical Properties
Liquid

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