LRP5 Antibody

• Background:

  Low density lipoprotein (LDL) receptor-related protein (LRP), a member of the LDL receptor family, binds multiple classes of ligands and has been implicated in a broad range of normal and disease processes involving lipid metabolism, protease clearance, and cell migration. Structurally, members of the LDLR family share homology within their extracellular domains, which are highlighted by the presence of clusters of ligand-binding repeats. LRP is a large endocytic receptor that participates in several biological pathways and plays prominent roles in lipoprotein metabolism and in the catabolism of proteinases involved in coagulation and fibrinolysis. LRP also mediates the cellular entry of certain viruses and toxins and facilitates the activation of various lysosomal enzymes. All LRPs are expressed in the central nervous system and, for most receptors, animal models have shown that they are indispensable for successful neurodevelopment. The mechanisms by which they regulate the formation of the nervous system are varied and include the transduction of extracellular signals and the modulation of intracellular signal propagation, as well as cargo transport, the function most commonly attributed to this gene family.

• NCBI Gene ID:

  4041

• Swiss Prot:

  O75197

• Accession Number:

  O75197

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This LRP5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1538-1567 amino acids from the C-terminal region of human LRP5.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Neuroscience, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  179 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  LRP5

• NCBI Official Name:

  Low-density lipoprotein receptor-related protein 5

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Grimsley PG, et al. Trends Cardiovasc Med. 1998:363

• Background Reference 02:

  Strickland DKRanganathan S.Thromb Haemost. 2003:1663

• Background Reference 03:

  Mayand Herz J. Traffic. 2003:291

• Other Product Names:

  Low-density lipoprotein receptor-related protein 5, LRP-5, LRP5, LR3, LRP7

• Tested Applications:

  WB, IHC-P

• Physical Properties:

  Liquid