LRP6 Antibody

• Background:

  LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.

• NCBI Gene ID:

  4040

• Swiss Prot:

  O75581

• Accession Number:

  O75581

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This LRP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1531-1560 amino acids from the C-terminal region of human LRP6.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  180 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  LRP6

• NCBI Official Name:

  Low-density lipoprotein receptor-related protein 6

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Liu, G., et al., Mol. Cell. Biol. 23 (16) :5825-5835 (2003) . Tamai, K., et al., Nature 407 (6803) :530-535 (2000) . Brown, S.D., et al., Biochem. Biophys. Res. Commun. 248 (3) :879-888 (1998) .

• Other Product Names:

  Low-density lipoprotein receptor-related protein 6, LRP-6, LRP6

• Tested Applications:

  WB, IHC-P

• Physical Properties:

  Liquid