PON2 Antibody

• Background:

  PON2 is a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes.

• NCBI Gene ID:

  5445

• Swiss Prot:

  Q15165

• Accession Number:

  Q15165

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This PON2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 74-101 amino acids from the Central region of human PON2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  39 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  PON2

• NCBI Official Name:

  Serum paraoxonase/arylesterase 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Sanghera, D.K., et al. Am. J. Hum. Genet. 62 (1) :36-44 (1998)

• Background Reference 02:

  Hegele, R.A., et al. J. Clin. Endocrinol. Metab. 82 (10) :3373-3377 (1997)

• Background Reference 03:

  Primo-Parmo, S.L., et al. Genomics 33 (3) :498-507 (1996)

• Other Product Names:

  Serum paraoxonase/arylesterase 2, PON 2, Aromatic esterase 2, A-esterase 2, Serum aryldialkylphosphatase 2, PON2

• Tested Applications:

  WB, IHC-P, IF

• Protein ID:

  325511384

• Physical Properties:

  Liquid