PON1 Antibody

• Background:

  The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3.

• NCBI Gene ID:

  5444

• Swiss Prot:

  P27169

• Accession Number:

  P27169

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PON1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 118-145 amino acids from the Central region of human PON1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Obesity, Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  40 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  PON1

• NCBI Official Name:

  Serum paraoxonase/arylesterase 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ergun, M.A., et al. Biochem. Genet. (2010) In press :

• Background Reference 02:

  Cagirci, G., et al. J. Heart Valve Dis. 19 (4) :453-458 (2010)

• Background Reference 03:

  Mendonca, M.I., et al. Rev Port Cardiol 29 (4) :571-580 (2010)

• Background Reference 04:

  Hashemi, M., et al. Genet. Mol. Res. 9 (3) :1735-1741 (2010)

• Other Product Names:

  Serum paraoxonase/arylesterase 1, PON 1, Aromatic esterase 1, A-esterase 1, K-45, Serum aryldialkylphosphatase 1, PON1, PON

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  308153572

• Physical Properties:

  Liquid