SYN3 Antibody

• Background:

  This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. The protein encoded by this gene shares the synapsin family domain model, with domains A, C, and E exhibiting the highest degree of conservation. The protein contains a unique domain J, located between domains C and E. Based on this gene's localization to 22q12.3, a possible schizophrenia susceptibility locus, and the established neurobiological roles of the synapsins, this family member may represent a candidate gene for schizophrenia. The TIMP3 gene is located within an intron of this gene and is transcribed in the opposite direction.

• NCBI Gene ID:

  8224

• Swiss Prot:

  O14994

• Accession Number:

  O14994

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This SYN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 363-388 amino acids from the Central region of human SYN3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  63 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  SYN3

• NCBI Official Name:

  Synapsin-3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Tsai, M.T., et al. Am. J. Med. Genet. 114 (1) :79-83 (2002)

• Background Reference 02:

  Kao, H.T., et al. J. Exp. Zool. 285 (4) :360-377 (1999)

• Background Reference 03:

  Porton, B., et al. J. Neurochem. 73 (6) :2266-2271 (1999)

• Background Reference 04:

  Kao, H.T., et al. Proc. Natl. Acad. Sci. U.S.A. 95 (8) :4667-4672 (1998)

• Other Product Names:

  Synapsin-3, Synapsin III, SYN3

• Tested Applications:

  WB, IHC-P

• Physical Properties:

  Liquid