SYNE3 Antibody

• Background:

  Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system.

• NCBI Gene ID:

  161176

• Swiss Prot:

  Q6ZMZ3

• Accession Number:

  Q6ZMZ3

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This SYNE3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 852-880 amino acids from the C-terminal region of human SYNE3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  112 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  SYNE3

• NCBI Official Name:

  Nesprin-3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Nery, F.C., et al. J. Cell. Sci. 121 (PT 20), 3476-3486 (2008) :

• Background Reference 02:

  Stewart-Hutchinson, P.J., et al. Exp. Cell Res. 314 (8) :1892-1905 (2008)

• Background Reference 03:

  Wilhelmsen, K., et al. J. Cell Biol. 171 (5) :799-810 (2005)

• Background Reference 04:

  Heilig, R., et al. Nature 421 (6923) :601-607 (2003)

• Other Product Names:

  Nesprin-3, Nuclear envelope spectrin repeat protein 3, SYNE3, C14orf49

• Tested Applications:

  WB, IHC-P

• Protein ID:

  134035037

• Physical Properties:

  Liquid