CFHR5 Antibody

• Background:

  CFHR5 is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS) . [provided by RefSeq].

• NCBI Gene ID:

  81494

• Swiss Prot:

  Q9BXR6

• Accession Number:

  Q9BXR6

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CFHR5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 203-231 amino acids from the Central region of human CFHR5.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  64 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CFHR5

• NCBI Official Name:

  Complement factor H-related protein 5

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  McRae, J.L., et al. Genetica 114 (2) :157-161 (2002)

• Background Reference 02:

  Murphy, B., et al. Am. J. Kidney Dis. 39 (1) :24-27 (2002)

• Background Reference 03:

  Narkio-Makela, M., et al. Clin. Immunol. 100 (1) :118-126 (2001)

• Background Reference 04:

  McRae, J.L., et al. J. Biol. Chem. 276 (9) :6747-6754 (2001)

• Other Product Names:

  Complement factor H-related protein 5, FHR-5, CFHR5, CFHL5, FHR5

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  23396597

• Physical Properties:

  Liquid