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CFHR5 Antibody

CAT: 0223-62-009Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-62-009Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CFHR5 is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS) . [provided by RefSeq].
NCBI Gene ID
81494
Swiss Prot
Q9BXR6
Accession Number
Q9BXR6
Host
Rabbit
Reactivity
Human
Immunogen
This CFHR5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 203-231 amino acids from the Central region of human CFHR5.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
64 kDa
Fragment
Rabbit Ig
Symbol
CFHR5
NCBI Official Name
Complement factor H-related protein 5
NCBI Organism
Homo sapiens
Background Reference 01
McRae, J.L., et al. Genetica 114 (2) :157-161 (2002)
Background Reference 02
Murphy, B., et al. Am. J. Kidney Dis. 39 (1) :24-27 (2002)
Background Reference 03
Narkio-Makela, M., et al. Clin. Immunol. 100 (1) :118-126 (2001)
Background Reference 04
McRae, J.L., et al. J. Biol. Chem. 276 (9) :6747-6754 (2001)
Other Product Names
Complement factor H-related protein 5, FHR-5, CFHR5, CFHL5, FHR5
Tested Applications
WB, IHC-P, Flow
Protein ID
23396597
Physical Properties
Liquid

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