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XRCC1 Antibody

CAT: 0223-61-969Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-61-969Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
NCBI Gene ID
7515
Swiss Prot
P18887
Accession Number
P18887
Host
Rabbit
Reactivity
Human
Immunogen
This XRCC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 407-435 amino acids from the Central region of human XRCC1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
69 kDa
Fragment
Rabbit Ig
Symbol
XRCC1
NCBI Official Name
DNA repair protein XRCC1
NCBI Organism
Homo sapiens
Background Reference 01
Lamerdin, J.E., et al. Genomics 25 (2) :547-554 (1995)
Background Reference 02
Gyapay, G., et al. Nat. Genet. (2 SPEC NO), 246-339 (1994) :
Background Reference 03
Thompson, L.H., et al. Mol. Cell. Biol. 10 (12) :6160-6171 (1990)
Background Reference 04
Thompson, L.H., et al. Genomics 5 (4) :670-679 (1989)
Other Product Names
DNA repair protein XRCC1, X-ray repair cross-complementing protein 1, XRCC1
Tested Applications
WB, IHC-P, IF, Flow
Protein ID
317373290
Physical Properties
Liquid

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