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XRCC4 Antibody

CAT: 0223-60-188Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-188Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V (D) J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative splicing generates several transcript variants. [provided by RefSeq].
NCBI Gene ID
7518
Swiss Prot
Q13426
Accession Number
Q13426
Host
Rabbit
Reactivity
Human
Immunogen
This XRCC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 205-234 amino acids from the Central region of human XRCC4.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
38 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
XRCC4
NCBI Official Name
DNA repair protein XRCC4
NCBI Organism
Homo sapiens
Background Reference 01
Gomes, B.C., et al. Oncol. Rep. 24 (4) :1079-1085 (2010)
Background Reference 02
Liu, Y., et al. Carcinogenesis 31 (10) :1762-1769 (2010)
Background Reference 03
Briggs, F.B., et al. Am. J. Epidemiol. 172 (2) :217-224 (2010)
Background Reference 04
Liu, N., et al. Wei Sheng Yan Jiu 39 (4) :407-411 (2010)
Other Product Names
DNA repair protein XRCC4, X-ray repair cross-complementing protein 4, XRCC4
Tested Applications
WB
Protein ID
44888352
Physical Properties
Liquid

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