TPSAB1 Antibody

• Background:

  Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.

• NCBI Gene ID:

  7177

• Swiss Prot:

  Q15661

• Accession Number:

  Q15661

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This TPSAB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 61-87 amino acids from the Central region of human TPSAB1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Immunology, Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  31 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  TPSAB1

• NCBI Official Name:

  Tryptase alpha/beta-1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Trivedi, N.N., et al. J. Allergy Clin. Immunol. 124 (5) :1099-1105 (2009)

• Background Reference 02:

  Radhakrishnan, Y., et al. Biol. Reprod. 81 (4) :647-656 (2009)

• Background Reference 03:

  Schiemann, F., et al. J. Immunol. 183 (4) :2223-2231 (2009)

• Other Product Names:

  Tryptase alpha/beta-1, Tryptase-1, Tryptase I, Tryptase alpha-1, TPSAB1, TPS1, TPS2, TPSB1

• Tested Applications:

  WB, Flow

• Protein ID:

  18202508

• Physical Properties:

  Liquid