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TPSAB1 Antibody

CAT: 0223-61-930Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-61-930Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.
NCBI Gene ID
7177
Swiss Prot
Q15661
Accession Number
Q15661
Host
Rabbit
Reactivity
Human
Immunogen
This TPSAB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 61-87 amino acids from the Central region of human TPSAB1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Immunology, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
31 kDa
Fragment
Rabbit Ig
Symbol
TPSAB1
NCBI Official Name
Tryptase alpha/beta-1
NCBI Organism
Homo sapiens
Background Reference 01
Trivedi, N.N., et al. J. Allergy Clin. Immunol. 124 (5) :1099-1105 (2009)
Background Reference 02
Radhakrishnan, Y., et al. Biol. Reprod. 81 (4) :647-656 (2009)
Background Reference 03
Schiemann, F., et al. J. Immunol. 183 (4) :2223-2231 (2009)
Other Product Names
Tryptase alpha/beta-1, Tryptase-1, Tryptase I, Tryptase alpha-1, TPSAB1, TPS1, TPS2, TPSB1
Tested Applications
WB, Flow
Protein ID
18202508
Physical Properties
Liquid

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