TPSD1 Antibody

CAT: 0223-55-222Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-55-222Size:400 µL
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Background
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. Although this gene may be an exception, most of the tryptase genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. TPSD1 was once considered to be a pseudogene, although it is now believed to be a functional gene that encodes a protein.
NCBI Gene ID
23430
Swiss Prot
Q9BZJ3
Accession Number
Q9BZJ3
Host
Rabbit
Reactivity
Human
Immunogen
This TPSD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 164-193 amino acids from the C-terminal region of human TPSD1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
27 kDa
Fragment
Rabbit Ig
Symbol
TPSD1
NCBI Official Name
Tryptase delta
NCBI Organism
Homo sapiens
Background Reference 01
Jackson, N.E., et al. J. Biol. Chem. 283 (49) :34178-34187 (2008)
Background Reference 02
Caughey, G.H. J. Allergy Clin. Immunol. 117 (6) :1411-1414 (2006)
Background Reference 03
Wang, H.W., et al. J. Immunol. 169 (9) :5145-5152 (2002)
Background Reference 04
Caughey, G.H. Mol. Immunol. 38 (16-18), 1353-1357 (2002) :
Other Product Names
Tryptase delta, Delta-tryptase, HmMCP-3-like tryptase III, Mast cell mMCP-7-like, Tryptase-3, TPSD1
Tested Applications
WB, IHC-P
Protein ID
239938722
Physical Properties
Liquid

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