IL5RA Antibody

• Background:

  IL5RA is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5) . The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4.

• NCBI Gene ID:

  3568

• Swiss Prot:

  Q01344

• Accession Number:

  Q01344

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This IL5RA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 49-76 amino acids from the N-terminal region of human IL5RA.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  48 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  IL5RA

• NCBI Official Name:

  Interleukin-5 receptor subunit alpha

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Matarin, M., et al. Stroke 40 (11) :3436-3442 (2009)

• Background Reference 02:

  Beekman, J.M., et al. Blood 114 (18) :3917-3927 (2009)

• Background Reference 03:

  Song, X.Y., et al. Diabetologia 52 (8) :1543-1553 (2009)

• Other Product Names:

  Interleukin-5 receptor subunit alpha, IL-5 receptor subunit alpha, IL-5R subunit alpha, IL-5R-alpha, IL-5RA, CDw125, CD125, IL5RA, IL5R

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  116242525

• Physical Properties:

  Liquid