MAP3K11 Antibody

• Background:

  MAP3K11 is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42.

• NCBI Gene ID:

  4296

• Swiss Prot:

  Q16584

• Accession Number:

  Q16584

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This MAP3K11 antibody is generated from rabbits immunized with MAP3K11 recombinant protein.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  93 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  MAP3K11

• NCBI Official Name:

  Mitogen-activated protein kinase kinase kinase 11

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Rangasamy, V., et al. Cancer Res. 70 (4) :1731-1740 (2010)

• Background Reference 02:

  Velho, S., et al. Hum. Mol. Genet. 19 (4) :697-706 (2010)

• Background Reference 03:

  Cole, E.T., et al. Biochim. Biophys. Acta 1793 (12) :1811-1818 (2009)

• Other Product Names:

  HGNC:6850

• Tested Applications:

  WB

• Protein ID:

  71153819

• Physical Properties:

  Liquid