TOX3 Antibody

• Background:

  TOX3 contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer.

• NCBI Gene ID:

  27324

• Swiss Prot:

  O15405

• Accession Number:

  O15405

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This TOX3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 214-242 amino acids from the Central region of human TOX3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  63 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  TOX3

• NCBI Official Name:

  TOX high mobility group box family member 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Wacholder, S., et al. N. Engl. J. Med. 362 (11) :986-993 (2010)

• Background Reference 02:

  Odefrey, F., et al. Cancer Res. 70 (4) :1449-1458 (2010)

• Background Reference 03:

  Couch, F.J., et al. Cancer Epidemiol. Biomarkers Prev. 18 (11) :3044-3048 (2009)

• Background Reference 04:

  Stacey, S.N., et al. Nat. Genet. 39 (7) :865-869 (2007)

• Other Product Names:

  TOX high mobility group box family member 3, CAG trinucleotide repeat-containing gene F9 protein, Trinucleotide repeat-containing gene 9 protein, TOX3, CAGF9, TNRC9

• Tested Applications:

  WB, IHC-P, Flow

• Physical Properties:

  Liquid