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FEN1 Antibody

CAT: 0223-61-554Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-61-554Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
FEN1 removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. This protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.
NCBI Gene ID
2237
Swiss Prot
P39748
Accession Number
P39748
Host
Rabbit
Reactivity
Human
Immunogen
This FEN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 243-272 amino acids from the Central region of human FEN1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
43 kDa
Fragment
Rabbit Ig
Symbol
FEN1
NCBI Official Name
Flap endonuclease 1 {ECO:0000255|HAMAP-Rule:MF_03140}
NCBI Organism
Homo sapiens
Background Reference 01
Hiraoka L.R., Harrington J.J., Gerhard D.S., Genomics 25:220-225 (1995)
Background Reference 02
Robins P., Pappin D.J.C., Wood R.D., Lindahl T.J. Biol. Chem. 269:28535-28538 (1994)
Background Reference 03
Gary R., Ludwig D.L., Cornelius H.L., MacInnes M.A., J. Biol. Chem. 272:24522-24529 (1997)
Other Product Names
Flap endonuclease 1 {ECO:0000255|HAMAP-Rule:MF_03140}, FEN-1 {ECO:0000255|HAMAP-Rule:MF_03140}, 31-- {ECO:0000255|HAMAP-Rule:MF_03140}, DNase IV, Flap structure-specific endonuclease 1 {ECO:0000255|HAMAP-Rule:MF_03140}, Maturation factor 1, MF1, hFEN-1, FEN1 {ECO:0000255|HAMAP-Rule:MF_03140}, RAD2
Tested Applications
WB, IF
Protein ID
729475
Physical Properties
Liquid

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