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LECT1 Antibody

CAT: 0223-61-461Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-61-461Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
LECT1 a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This protein is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development.
NCBI Gene ID
11061
Swiss Prot
O75829
Accession Number
O75829
Host
Rabbit
Reactivity
Human
Immunogen
This LECT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 253-281 amino acids from the C-terminal region of human LECT1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rabbit, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
37 kDa
Fragment
Rabbit Ig
Symbol
LECT1
NCBI Official Name
Leukocyte cell-derived chemotaxin 1
NCBI Organism
Homo sapiens
Background Reference 01
Aoyama, T., Biochem. Biophys. Res. Commun. 365 (1), 124-130 (2008)
Background Reference 02
Yoshioka, M., Nat. Med. 12 (10), 1151-1159 (2006)
Background Reference 03
Aoyama, T., J. Biol. Chem. 279 (27), 28789-28797 (2004)
Other Product Names
Leukocyte cell-derived chemotaxin 1, Chondrosurfactant protein, CH-SP, Chondromodulin-1, Chondromodulin-I, ChM-I, LECT1, CHMI
Tested Applications
WB, IHC-P
Physical Properties
Liquid

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