SMC2 Antibody

• Background :

  SMC2 is a central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

• NCBI Gene ID :

  10592

• Swiss Prot :

  O95347

• Accession Number :

  O95347

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This SMC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1166-1197 amino acids from the C-terminal region of human SMC2.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cell Cycle

• Purification :

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  136 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  SMC2

• NCBI Official Name :

  Structural maintenance of chromosomes protein 2

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Schmiesing, J.A., Proc. Natl. Acad. Sci. U.S.A. 95 (22), 12906-12911 (1998)

• Background Reference 02 :

  Ham, M.F., Cancer Sci. 98 (7), 1041-1047 (2007)

• Other Product Names :

  Structural maintenance of chromosomes protein 2, SMC protein 2, SMC-2, Chromosome-associated protein E, hCAP-E, XCAP-E homolog, SMC2, CAPE, SMC2L1

• Tested Applications :

  WB

• Physical Properties :

  Liquid