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SMC3 Antibody

CAT: 0223-58-027Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-027Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein.
NCBI Gene ID
9126
Swiss Prot
Q9UQE7
Accession Number
Q9UQE7
Host
Rabbit
Reactivity
Human
Immunogen
This SMC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 402-430 amino acids from the Central region of human SMC3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
142 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
SMC3
NCBI Official Name
Structural maintenance of chromosomes protein 3
NCBI Organism
Homo sapiens
Background Reference 01
Pie, J., et al. Am. J. Med. Genet.152A (4), 924-929 (2010) :
Background Reference 02
Terret, M.E., et al. Nature 462 (7270) :231-234 (2009)
Background Reference 03
Revenkova, E., et al. Hum. Mol. Genet. 18 (3) :418-427 (2009)
Background Reference 04
Ridinger, H., et al. Exp. Mol. Pathol. 86 (1) :23-31 (2009)
Other Product Names
Structural maintenance of chromosomes protein 3, SMC protein 3, SMC-3, Basement membrane-associated chondroitin proteoglycan, Bamacan, Chondroitin sulfate proteoglycan 6, Chromosome-associated polypeptide, hCAP, SMC3, BAM, BMH, CSPG6, SMC3L1
Tested Applications
WB
Protein ID
29337005
Physical Properties
Liquid

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